Latest News

EASL publishes Clinical Practice Guidelines for Wilson Disease
The European Association for the study of the Liver (EASL) has published a Clinical Practice Guideli... more...
4th March 2014
New capsule shell Logo on Trientine capsules
For many years Univar has supplied  Trientine Dihydrochloride 300mg capsules (Trientine) in a p... more...
1st March 2014
New Customer Service Number
Effective from Monday the 24th of January 2011, the contact details for Customer Services are changi... more...
1st January 2011
New 500 capsules unit packaging
Univar has been listening to the concerns of our German patients around the possibility of Univ... more...
15th April 2010
Trientine Compassionate Use Program
Univar Ltd is pleased to announce that with effect from March 1st 2010, qualified patients in design... more...
15th April 2010
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Wilson Disease and Trientine Dihydrochloride

Wilson Disease, also known as hepatolenticular degeneration, is a rare inherited autosomal recessive disorder of copper metabolism, resulting in copper toxicity and dysfunction of several organs such as the liver, central nervous system, eyes and kidneys. The disease has a gene frequency of 1 in 90-150 and an incidence of 1 in 30,000.

Untreated Wilson Disease is universally fatal, with most patients dying from liver disease and a minority from complications of progressive neurologic disease. The goal of drug therapy is to remove excess copper from the body and prevent ongoing copper accumulation and deposition. Treatment for WD is lifelong. Liver transplantation which corrects the underlying hepatic defect in WD is reserved for severe or resistant cases only

Wilson Disease is a very treatable condition. Trientine dihydrochloride, a chelating agent, is indicated for the treatment of Wilson Disease in patients who are intolerant of D-Penicillamine therapy or have clinical features indication potential intolerance.

Univar has been manufacturing and supplying Trientine dihydrochloride for the treatment of Wilson Disease patients since 1985.


This website is intended for information purposes only.

Each patient is strongly advised to consult with their physician about their individual cases.